Potensi Tanaman Sebagai Pencerah Wajah Alami
DOI:
https://doi.org/10.25026/jsk.v2i4.233Keywords:
Hyperpigmentation, Plants, Tyrosinase InhibitorsAbstract
Melanin is a pigment that gives human skin, hair and eye color. Excessive distribution of pigment malanin can cause skin problems such as hyperpigmentation. One of the principles of handling hyperpigmentation is to inhibit melanin synthesis which can be done by using a depigmentation agent (tyrosinase inhibitor) which has a mechanism of action to inhibit the tyrosinase enzyme. Inhibition of the tyrosinase enzyme can be done by measuring IC50 in a plant. IC50 is the concentration of an inhibitor needed to inhibit half of the enzyme activity. This review aims to compare the IC50 values ??of monophenolase activity and IC50 diphenolase activity in some plants that have tyrosinase inhibitory activity with invitro testing methods on L-tyrosine or L-DOPA substrates. The results of the study of several articles found that the plants that have the best potential to reward tyrosinase enzyme activity are sweet root extract (Glycyrrhiza glabra L.) with IC50 value 126.7548 µg / mL on the activity of diphenolase and extract of bark (Nauclea subdita) with IC50 value of 568.58 µg / mL on monofenolase activity.
References
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[17] M. N. Asl and H. Hosseinzadeh, “Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds,” Phyther. Res., vol. 22, no. 4, pp. 544–549, 2008, doi: 10.1002/ptr.
[18] M. Gazali, N. P. Zamani, and I. Batubara, “Potensi limbah kulit buah Nyirih Xylocarpus granatum sebagai inhibitor tirosinase,” Depik, vol. 3, no. 3, pp. 187–194, 2014, doi: 10.13170/depik.3.3.2153.
[19] D. Kim et al., “Flavonoids as mushroom tyrosinase inhibitors: A fluorescence quenching study,” J. Agric. Food Chem., vol. 54, no. 3, pp. 935–941, 2006, doi: 10.1021/jf0521855.
[20] S. Y. Lee, N. Baek, and T. G. Nam, “Natural, Semisynthetic and Synthetic
[2] G. Carletti, G. Nervo, and L. Cattivelli, “Flavonoids and melanins: A common Strategy Across Two Kingdoms,” Int. J. Biol. Sci., vol. 10, no. 10, pp. 1159–1170, 2014, doi: 10.7150/ijbs.9672.
[3] M. N. Masum, K. Yamauchi, and T. Mitsunaga, “Tyrosinase Inhibitors from Natural and Synthetic Sources as Skin-lightening Agents,” Rev. Agric. Sci., vol. 7, pp. 41–58, 2019, doi: 10.7831/ras.7.41.
[4] M. Cichorek, M. Wachulska, A. Stasiewicz, and A. Tymi?ska, “Skin Melanocytes: Biology and Development,” Postep. Dermatologii i Alergol., vol. 30, no. 1, pp. 30–41, 2013, doi: 10.5114/pdia.2013.33376.
[5] Y. J. Kim, J. K. No, J. H. Lee, and H. Y. Chung, “4,4?-Dihydroxybiphenyl As a New Potent Tyrosinase Inhibitor,” Biol. Pharm. Bull., vol. 28, no. 2, pp. 323–327, 2005, doi: 10.1248/bpb.28.323.
[6] T. S. Chang, “An updated Review of Tyrosinase Inhibitors,” Int. J. Mol. Sci., vol. 10, no. 6, pp. 2440–2475, 2009, doi: 10.3390/ijms10062440.
[7] J. O. Owolabi, O. S. Fabiyi, L. A. Adelakin, and M. C. Ekwerike, “Effects of Skin Lightening Cream Agents - Hydroquinone and Kojic Acid, on the Skin of Adult Female Experimental Rats,” Clin. Cosmet. Investig. Dermatol., vol. 13, pp. 283–289, 2020, doi: 10.2147/CCID.S233185.
[8] M. Sholikha, A. Febriani, and A. Wahyuningrum, “Formulasi Gel Ekstrak Lobak ( Raphanus sativus L . ) Sebagai Antioksidan dan Inhibitor Tirosinase,” J. Ilmu Kefarmasian, vol. 13, no. 1, pp. 15–20, 2020.
[9] A. Kurniasari, E. Anwar, and J. Djajadisastra, “Potensi Ekstrak Biji Coklat (Theobroma cacao Linn) sebagai Inhibitor Tirosinase untuk Produk Pencerah Kulit,” J. Kefarmasian Indones., vol. 8, no. 1, pp. 34–43, 2018, doi: 10.22435/jki.v8i1.7722.34-43.
[10] Z. Abidin, U. Khaeriah, Z. Zuhrina, M. Pratama, and M. Baits, “Tyrosinase Inhibitor Activity Measurement of Crude and Purified Extract of Moringa Leaves (Moringa oleifera L.),” Indones. J. Pharm. Sci. Technol., vol. 1, no. 1, 2019, doi: 10.24198/IJPST.V1I1.19152.
[11] S. Hindun, T. Rusdiana, M. Abdasah, and R. Hindritiani, “POTENSI LIMBAH KULIT JERUK NIPIS (Citrus auronfolia) SEBAGAI INHIBITOR TIROSINASE,” Indones. J. Pharm. Sci. Technol., vol. 4, no. 2, p. 64, 2017, doi: 10.15416/ijpst.v4i2.12642.
[12] Z. Sagala, R. W. Pratiwi, N. U. Azmi, and Maap, “Uji Aktivitas Inhibisi terhadap Enzim Tirosinase dari Ekstrak Etanol Daun Pepaya ( Carica papaya L .) Secara In Vitro,” J. Penelit. Farm. Indones., vol. 7, no. 2, pp. 34–38, 2019.
[13] M. Charissa, J. Djajadisastra, and B. Elya, “Uji Aktivitas Antioksidan dan Penghambatan Tirosinase serta Uji Manfaat Gel Ekstrak Kulit Batang Taya (Nauclea subdita) terhadap Kulit,” J. Kefarmasian Indones., vol. 6, no. 2, pp. 98–107, 2017, doi: 10.22435/jki.v6i2.6224.98-107.
[14] S. Umrah Noor and P. Magdalena, “Uji Aktivitas Inhibisi Enzim Tirosinase In-Vitro Krim Ekstrak Akar Manis (Glycyrrhiza glabra L.),” J. Ilmu Kefarmasian Indones., vol. 16, no. 2, pp. 150–158, 2018.
[15] H. C. Himawan, A. P. Ratu, and M. Miani, “Uji Aktivitas Ekstrak Etanol 70% dan Etil Asetat Daun Sukun (Artocarpus altilis (Park.) Fosberg Sebagai Inhibitor Tirosinase,” J. Farmamedika., vol. 1, no. 2, pp. 63–69, 2016.
[16] T. Yokota, H. Nishio, Y. Kubota, and M. Mizoguchi, “The Inhibitory Effect of Glabridin from Licorice Extracts on Melanogenesis and Inflammation,” Pigment Cell Res., vol. 11, no. 6, pp. 355–361, 1998, doi: 10.1111/j.1600-0749.1998.tb00494.x.
[17] M. N. Asl and H. Hosseinzadeh, “Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds,” Phyther. Res., vol. 22, no. 4, pp. 544–549, 2008, doi: 10.1002/ptr.
[18] M. Gazali, N. P. Zamani, and I. Batubara, “Potensi limbah kulit buah Nyirih Xylocarpus granatum sebagai inhibitor tirosinase,” Depik, vol. 3, no. 3, pp. 187–194, 2014, doi: 10.13170/depik.3.3.2153.
[19] D. Kim et al., “Flavonoids as mushroom tyrosinase inhibitors: A fluorescence quenching study,” J. Agric. Food Chem., vol. 54, no. 3, pp. 935–941, 2006, doi: 10.1021/jf0521855.
[20] S. Y. Lee, N. Baek, and T. G. Nam, “Natural, Semisynthetic and Synthetic
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Published
2020-12-31
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1.
Mustika R, Hindun S, Auliasari N. Potensi Tanaman Sebagai Pencerah Wajah Alami. J. Sains Kes. [Internet]. 2020 Dec. 31 [cited 2025 Nov. 1];2(4):558-62. Available from: https://jsk.jurnalfamul.com/index.php/jsk/article/view/233
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