Preparasi dan Karakteristik Floating Tablet Ekstrak Daun Jambu Biji (Psidium guajava L.) dengan Variasi Kombinasi Xanthan Gum dan HPMC
Preparation and Characteristics of Floating Tablets of Guava Leaf Extract (Psidium guajava L.) With Variations of Xanthan Gum and HPMC Combinations
DOI:
https://doi.org/10.25026/jsk.v4i4.1226Keywords:
floating tablet, guava leaf extract, gastritis, HPMCAbstract
Floating drug delivery system (FRDDS) is a new drug delivery system that is intended to prolong the time of drugs in the stomach. One form of the gastroretentive system is a floating tablet, which can float and stay in the stomach for some time. Preparations with this system are suitable for use in drugs that have an action on the stomach. Gastritis is defined as an inflammation or swelling of the inner lining of the stomach. Guava leaves are proven to have active ingredients that can act as anti-ulcers. This study aims to formulate floating tablets and determine the optimal combination of HPMC with xanthan gum in the formulation of floating tablets of guava leaf extract based on flotation testing and in vitro dissolution profiles. The extract was made using maceration method with 96% ethanol as solvent. The tablets were made in a number of 3 formulas using the wet granulation method. Each tablet weighed 500 mg with a combination of various types of HPMC K100M, HPMC K15M, HPMC K4M with xanthan gum as a floating agent. The formula produced the best tablet quality with a combination of HPMC K100M and xanthan gum as a floating agent. Based on the results of the in vitro dissolution profile, the drug release rate ranged from 23,604% - 26,846% with in 360 minutes (6 hours).
References
Utami, C. P., Choesrina, R., Suwendar, 2017. Uji Aktivitas Antitukak Lambung Ekstrak Etanol Daun Jambu Biji (Psidium guajava Linn.) Berdaging Buah Putih terhadap Tikus Wistar Jantan yang Diinduksi Aspirin, Prosiding Farmasi Universitas Islam Bandung, Volume 3, (2), page 570-578.
Kementerian Kesehatan RI. 2017. Farmakope Herbal Indonesia. Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan.
Rogers, T. L., 2009, Hypromellose, in : Rowe, R. C., Sheckey, P. J., & Quinn, M. E. (eds.). Handbook of Pharmaceutical Excipients, Sixth Edition. Pharmaceutical Press and American Pharmacists Association. London.
Agatha, G. A. 2017. Optimasi Formula Floating Tablet Ranitidin HCl dengan Kombinasi Matriks HPMC dan Na-CMC Menggunakan Metode Simplex Lattice Design. Skripsi. Fakultas Farmasi Universitas Muhammadiyah.
Radhakrishna, M., K.G. Parthiban, Nelluri, R., Nagapuri, S.D. & Perumulla A. 2012. Formulation and Evaluation of Floating Drug Delivery System of Amooxycillin Trihydrate. IRJP.Volume 3 (8),pages 233-237.
Williams, J. C., T. Allen. 2007. Handbook of Powder Technology Granulation. 11.
Siregar, Charles J.P. dan Wikarsa, S. 2010. Teknologi Farmasi Sediaan Tablet Dasar-Dasar Praktis. Cetakan II. EGC. Jakarta.
Lieberman, H. A. 1990. Pharmaceutical Dosage Forms. New York: Marcel Dekker, Inc.
Chandiran S, Sivakumar T, Kumar BP, 2010. Preparation and evaluation of aceclofenac loaded biodegradable microspheres, International Journal of Pharmaceutical and Biomedical Research, Volume 1, (1), pages 19-23.
Handarni, D., Putri, H.S., Tensiska, 2020. Skrining Kualitatif Fitokimia Senyawa Antibakteri pada Ekstrak Daun Jambu Biji (Psidium guajava L.), Jurnal Keteknikan Pertanian Tropis dan Biosistem, Volume 8, (2).
Sari, S.P., Bestari. A.N., Sulaiman, T.N.S, 2019. Optimasi Formula Tablet Floating Famotidin Menggunakan Kombinasi Matriks Gum Xanthan dan Hidroksi Propil Metil Selulosa K100M, Majalah Farmaseutik, Volume 15, (2), page 86-95.
Aisiyah, S., Fudholi, A., Rohman, A, 2013. Optimasi Formula Tablet Floating Nifedipin Menggunakan HPMC K15M, PVP K-30 dan Avicel PH 102 dengan Metode Simplex Lattice Design, Journal of Pharmacy Volume 2, (1), page 38-46.
Aulton, M.E., 2002. Pharmaceutics: The Sciences of Dosage Form. 2nd Edition. Churchill Livingstone: London, United Kingdom.
Departemen Kesehatan RI, 1995. Farmakope Indonesia Edisi IV. Jakarta: Departemen Kesehatan RI.
Yanuar, R. F., Saifullah, T.N., Kuncahyo Ilham, 2015. Optimasi Formulasi Tablet Sustained Release Dan HPMC K15M Sebagai Matriks Mukoadhesif Secara Simplex Lattice Design, Majalah Farmaseutik, Volume 11, (3).
Siswanto, A. dan Sulihtyowati, S, 2006. Optimasi Formulasi Sediaan Tablet Lepas Lambat Teofilin dengan Bahan Matrik HPMC, Na CMC dan Gum xanthan, Majalah Farmasi Indonesia, Volume 17, (3), page 143-148.
Devi, I.A.S., Q.A. Shodiquna, N.W.S.D.Eni, C.I.S. Arisanti, P.O. Samirana, 2018. Optimasi Konsentrasi Polivinil Pirolidon (PVP) sebagai Bahan Pengikat tehadap Sifat Fisik Tablet Ekstrak Etanol Rimpang Bangle (Zingiber cassumunar Roxb), Jurnal Farmasi Udayana, Volume 7, (2), page 45-52.
Sagita, E., Anwar, E., Surini, S, 2013. Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks, Majalah Ilmu Kefarmasian, Volume 8, (1), page 1-56.
Akbar, H. F., Sugiyartono, Setiawan, D, 2012. Pengaruh Penambahan Manitol terhadap Pelepasan Ranitidin HCl dari Tablet Floating dengan HPMC K100M sebagai matriks, Pharma Scientia, Volume 1, (1), page 30-45.
Ulla, S.N., Roy, A.K., Kulkarni, M., Vinod,K.S.N, 2011. Formulation and Evaluation Of Sustained Release Matrix Tablets of Lornoxicam, International Journal of Drug Development & Research, Volume 3, (1), page 31 – 44.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jurnal Sains dan Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
