Stadium dan Tipe Histopatologi Kanker Serviks pada Pasien Kanker Serviks dengan Kemoradiasi di RSUD Abdoel Wahab Sjahranie Samarinda Periode 2021-2022

Stage and Histopathology Type of Cervical Cancer in Cervical Cancer Patients with Chemoradiation at Abdoel Wahab Sjahranie Hospital Samarinda 2021-2022 Periods

Authors

  • Anggita Maharani Program Studi Kedokteran, Fakultas Kedokteran, Universitas Mulawarman, Samarinda, Indonesia
  • Nurul Hasanah Laboratorium Histologi, Fakultas Kedokteran, Universitas Mulawarman, Samarinda, Indonesia
  • Andika Adi Saputra Achmad Laboratorium Ilmu Obstetri Ginekologi, Fakultas Kedokteran, Universitas Mulawarman, Samarinda, Indonesia
  • Novia Fransiska Ngo Laboratorium Ilmu Obstetri Ginekologi, Fakultas Kedokteran, Universitas Mulawarman, Samarinda, Indonesia
  • Endang Sawitri Laboratorium Fisiologi, Fakultas Kedokteran, Universitas Mulawarman, Samarinda, Indonesia https://orcid.org/0000-0002-7770-4706

DOI:

https://doi.org/10.25026/jsk.v7i3.2447

Abstract

Cervical cancer is a malignancy resulting from the uncontrolled development of cells in the cervix, making it the second most prevalent form of cancer in Indonesia. Currently, cancer treatments comprise surgical intervention, chemotherapy, and radiotherapy, or in conjunction, depending on the stage of the disease. This study aims to identify the stage and histopathological type of cervical cancer in cervical cancer patients with chemoradiation as well as urea levels and creatinine levels before patients underwent chemoradiation at Abdoel Wahab Sjahranie Regional Public Hospital Samarinda between 2021 and 2022. A cross-sectional study design was employed, encompassing 116 medical record data. Overall, the majority of cervical cancer patients who receive chemoradiation were in the histophatological type of squamous cell carcinoma (75%), predominantly at Stage II (64,3%), have anemia in their hemoglobin  levels (57,8%), and normal levels of urea and creatinine were (75%) and (91,4%) respectively.

Keywords:          cervical cancer, chemoradiation, histopathological type, stage, creatinine

 

Abstrak

Kanker serviks merupakan keganasan yang disebabkan oleh pertumbuhan sel yang tidak terkendali pada leher rahim, menduduki urutan kedua kanker terbanyak di Indonesia. Pengobatan kanker meliputi terapi pembedahan, kemoterapi, dan radioterapi, atau kombinasi sesuai dengan stadium. Tujuan penelitian ini adalah untuk mengetahui stadium dan tipe histopatologi kanker serviks pada pasien kanker serviks dengan kemoradiasi serta kadar ureum dan kadar kreatinin sebelum pasien menjalani kemoradiasi di RSUD Abdoel Wahab Sjahranie Samarinda periode 2021-2022. Desain penelitian cross-sectional menggunakan 116 data rekam medis. Hasil penelitian menunjukkan bahwa pasien kanker serviks terbanyak pada kelompok tipe histopatologi karsinoma sel skuamosa (75%), stadium pasien kanker serviks terbanyak adalah stadium II (64,3%), dan kadar hemoglobin terbanyak pada kelompok anemia (57,8%), serta kadar ureum dan kreatinin masing-masing pada kelompok normal sebesar (75%) dan (91,4%).

Kata Kunci:         kanker serviks, kemoradiasi, tipe histopatologi, stadium, kreatinin

 

References

Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. 10th ed. Philadelphia: Elsevier; 2018. 717–720 p.

Evriarti PR, Yasmon A. Patogenesis Human Papillomavirus (HPV) pada Kanker Serviks. J Biotek Medisiana Indones. 2019;8(1):23–32.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin [Internet]. 2018 Nov 1;68(6):394–424. Available from: https://doi.org/10.3322/caac.21492

Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the Cervix Uteri: 2021 update. Int J Gynecol Obstet [Internet]. 2021;28–44. Available from: https://doi.org/10.1002/ijgo.13865

Pandey U. What is Cervical Cancer? J Gynecol Womens Heal. 2017;2(5):1–9.

Herlana F, Nur IM, Purbaningsih W. Karakteristik pasien kanker serviks berdasar atas usia, paritas, dan gambaran histopatologi di RSUD Al-Ihsan Bandung. In: Bandung Meeting on Global Medicine & Health (BaMGMH). 2017. p. 138–42.

Alia R, Mastutik G, Hoesin F. Ekspresi Protein HPV16 E6/18 E6 dan Protein P53 pada Adenokarsinoma Serviks. Maj Patol Indones. 2016;25(1).

Putri FR, Sofian A, Nugraha DP. Gambaran Hasil Terapi Radiasi dan Kemoradiasi Pasien Kanker Serviks di RSUD Arifin Achmad Pekanbaru Periode 2009-2013. Riau University; 2014.

Aditiyono A, Sutrisno S, Priyanto E. Characteristics of Cervical Cancer Patients Under 40 Years Old at Regional General Hospital Prof Dr Margono Soekarjo Purwokerto Period January 1–December 31 2022. Med Heal J. 2023;2(2):53–61.

Pranata KKG, Yuseran H, Yasmina A, Armanza F, Mashuri M. Perbedaan Kadar MCV dan MCHC pada Pasien Kanker Serviks dengan Perdarahan dan Tanpa Perdarahan. Homeostasis. 2023;6(1):183–90.

Morita SE, Prabowo WC, Rijai L. Kajian Pengobatan Pasien Kanker Serviks di RSUD Abdul Wahab Sjahranie Samarinda. 2016;

Legianawati D, Puspitasari IM, Suwantika A, Kusumadjati A. Profil Penatalaksanaan Kanker Serviks Stadium IIB–IIIB dengan Terapi Radiasi dan Kemoradiasi di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Periode Tahun 2015–2017. Indones J Clin Pharm. 2019 Sep 29;8.

Macciò A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, et al. The Role of Inflammation, Iron, and Nutritional Status in Cancer-Related Anemia: Results of A Large, Prospective, Observational Study. Haematologica. 2015 Jan;100(1):124–32.

Busti F, Marchi G, Ugolini S, Castagna A, Girelli D. Anemia and iron deficiency in cancer patients: role of iron replacement therapy. Pharmaceuticals. 2018;11(4):94.

Suwiyoga IK. Penanganan Nyeri pada Kanker Serviks Stadium Lanjut. J Stud Jender Srikandi. 2017;

Abdus-salam AA, Bojude AD, Abdus-salam RA. Renal Status of Patients with Cervical Cancer Prior to Treatment Commencement. Trop J Nephrol. 2009;4(1):17–20.

Verdiansah V. Pemeriksaan Fungsi Ginjal. Cermin Dunia Kedokt. 2016;43(2):148–54.

Amin Y, Mulawardhana P, Erawati D. Demografi, Respon Terapi dan Survival rate Pasien Kanker Serviks Stadium III-IVA yang Mendapat Kemoterapi Dilanjutkan Radioterapi. Maj Obstet Ginekol. 2015;23(3):97.

Chino J, Annunziata CM, Beriwal S, Bradfield L, Erickson BA, Fields EC, et al. Radiation therapy for cervical cancer: executive summary of an ASTRO clinical practice guideline. Pract Radiat Oncol. 2020;10(4):220–34.

Hadi S, Iskandar M. Hubungan anemia dan transfusi darah terhadap respons kemoradiasi pada karsinoma serviks uteri stadium IIB-IIIB. Medica Hosp J Clin Med. 2012;1(1).

Masturoh I, Temesvari NA. Metodologi Penelitian Kesehatan. Kementerian Kesehatan Republik Indonesia. Jakarta; 2018.

Mahrus HW, Sudiarta IKE, Nawangsasi P, Diarsvitri W. Karakteristik dan Gambaran Histopatologi Ca Serviks di RSPAL Dr. Ramelan Surabaya Periode 2019-2021. Surabaya Biomed J. 2023;2(3):159–68.

Fuadi A, Pradjatmo H, Kusumanto A. Kualitas Hidup Satu Tahun Pasien Kanker Serviks yang telah Dilakukan Histerektomi Radikal di RSUP DR. Sardjito Yogyakarta. J Kesehat Reproduksi. 2019;6(3):115–22.

Sahiratmadja E, Tobing MDL, Dewayani BM, Hernowo BS, Susanto H. Multiple human papilloma virus infections predominant in squamous cell cervical carcinoma in Bandung. Universa Med [Internet]. 2014 Apr 19;33(1 SE-Review Article):58–64. Available from: https://univmed.org/ejurnal/index.php/medicina/article/view/40

Suwendar, Fudholi A, Andayani TM, Sastramihardja H. Evaluasi Outcome Klinik Regimen Kemoterapi Berbasis Cisplatin Terhadap Pasien Kanker Serviks. Pros Semin Nas Penelit dan PKM Kesehat. 2016;6(I):13–8.

Bahar I, Tjokroprawiro BA, Suhatno DE. Radiotherapy Response of Advanced Squamous and AdenocarcinomaTypes of Cervical Cancer at Dr Soetomo Hospital Surabaya. Maj Obstet Ginekol. 2013;21:48–55.

HOGI. Pedoman Nasional Pelayanan Kedokteran Kanker Ginekologi. Himpun Onkol Ginekol Indones. 2018;

Friyadi MH, Askandar B. Perbandingan operabilitas setelah pemberian kemoterapi neoadjuvant cisplatin dan paclitaxel carboplatin pada kanker serviks IIB di Divisi Ginekologi Onkologi RSUD Dr. Soetomo. Maj Obstet Ginekol. 2014;22(1):13–21.

Suryapratama SA, Pramono BA. Karakteristik Penderita Kanker Serviks Di RSUP Dr. Kariadi Semarang Tahun 2010. J Kedokt Diponegoro. 2012;1(1).

Ulfa LH, Andriansyah, Iskandar A. Hubungan Kadar Hemoglobin Sebelum dan Selama Terapi Radiasi dengan Respon Tumor pada Pasien Kanker Serviks di RSUD Abdul Wahab Sjahranie Samarinda. J Sains dan Kesehat. 2021;3(1):242–7.

Nasution HN. Kaheksia Kanker dan Tatalaksana Nutrisi pada Penderita Kanker. J Kedokt Syiah Kuala. 2021;21(2).

Satriotomo NA. Pengaruh Kemoradiasi dengan CisplatinTerhadap Fungsi Ginjal pada Pasien Karsinoma Serviks. Univ Diponegoro. 2011;1–22.

Noviyani R, Suwiyoga K, Dewi A, Niruri R, Tunas IK, Budiana I. Evaluation of Blood Urea Nitrogen and Serum Creatinine in Squamous Cell Cervical Cancer Patients Stadium IIb-IIIb Who Receiving Paclitaxel- Carboplatin Chemotherapy. Indones J Clin Pharm. 2014 Jun 1;3:55–60.

Berliana AH, Hariadi H, Hendriyono FX. Gambaran Kadar Kreatinin Darah pada Pasien Kanker Serviks yang Menerima Kemoterapi. Homeostasis. 2020;3(2):283–8.

Downloads

Published

2025-05-24

How to Cite

1.
Maharani A, Hasanah N, Achmad AAS, Ngo NF, Sawitri E. Stadium dan Tipe Histopatologi Kanker Serviks pada Pasien Kanker Serviks dengan Kemoradiasi di RSUD Abdoel Wahab Sjahranie Samarinda Periode 2021-2022: Stage and Histopathology Type of Cervical Cancer in Cervical Cancer Patients with Chemoradiation at Abdoel Wahab Sjahranie Hospital Samarinda 2021-2022 Periods. J. Sains Kes. [Internet]. 2025 May 24 [cited 2025 Oct. 26];7(3):159-65. Available from: https://jsk.jurnalfamul.com/index.php/jsk/article/view/2447

Issue

Vol. 7 No. 3 (2025): J. Sains Kes.

Section

Articles

License

Copyright (c) 2025 Jurnal Sains dan Kesehatan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Most read articles by the same author(s)

1 2 > >>