Kadar SGOT, SGPT, dan Kreatinin Pasien Orang dengan Human Immunodeficiency Virus (ODHIV) dengan Pengobatan ARV lebih dari 6 Bulan di Rumah Sakit X
SGOT, SGPT, and Creatinine Levels in Human Immunodeficiency Virus Patients with more than 6 Months of ARV Treatment at Hospital X
DOI:
https://doi.org/10.25026/jsk.v7i6.2566Abstract
HIV infection is one of the major health problems that progressively affects the body's immune system. Long-term antiretroviral (ARV) treatment, although effective in suppressing viral progression, can cause side effects on vital organ functions such as the liver and kidneys. This study aims to determine the results of SGOT, SGPT, and creatinine level tests in HIV-positive patients who have undergone ARV treatment for ? 6 months at Hospital X Jayapura in 2025. This descriptive study used a laboratory experimental approach on blood serum samples from HIV-positive patients who had undergone ARV treatment for ? 6 months, collected using purposive sampling. The tests were performed using a Sysmex BX-4000 Chemistry Analyzer. The results of the SGOT, SGPT, and creatinine level tests showed that out of 30 HIV-positive patients (100%) who had been on ARV treatment for ? 6 months, 17 patients (56.67%) had normal SGOT levels, 4 patients (13.33%) had low levels, and 9 patients (30%) had high levels. SGPT levels were normal in 16 patients (53.33%), low in 9 patients (30%), and high in 5 patients (16.67%). Creatinine levels were normal in 23 patients (76.67%), low in 2 patients (16.66%), and high in 5 patients (16.67%).
Keywords: HIV-Positive Patients, ARV, SGOT, SGPT, Creatinine
Abstrak
Infeksi HIV merupakan salah satu masalah kesehatan utama yang memengaruhi sistem imun tubuh secara progresif. Pengobatan antiretroviral (ARV) jangka panjang, meskipun efektif dalam menekan perkembangan virus, dapat menimbulkan efek samping terhadap fungsi organ vital seperti hati dan ginjal. Penelitian ini bertujuan untuk mengetahui hasil pemeriksaan kadar SGOT, SGPT, dan kreatinin pada pasien ODHIV yang telah menjalani pengobatan ARV selama ? 6 bulan di Rumah Sakit X Jayapura Tahun 2025. Jenis penelitian ini menggunakan metode deskriptif dengan pendekatan eksperimental laboratorium terhadap sampel serum darah pasien ODHIV yang telah pengobatan ARV ? 6 bulan yang diambil secara Purposive Sampling. Pemeriksaan dilakukan menggunakan alat Chemistry Analyzer Sysmex BX-4000. Hasil pemeriksaan kadar SGOT, SGPT dan Kreatinin menunjukkan bahwa dari 30 pasien (100%) ODHIV dengan pengobatan ARV ? 6 bulan yang diperiksa diperoleh hasil pemeriksaan kadar SGOT normal sebanyak 17 pasien (56,67%), rendah sebanyak 4 pasien (13,33%) dan tinggi sebanyak 9 pasien (30%). Kadar SGPT normal sebanyak 16 pasien (53,33%), rendah sebanyak 9 pasien (30%) dan tinggi sebanyak 5 pasien (16,67%). Kadar Kreatinin normal sebanyak 23 pasien (76,67%), hasil kadar rendah sebanyak 2 pasien (16,66%) dan tinggi sebanyak 5 pasien (16,67%).
Kata Kunci: ODHIV, ARV, SGOT, SGPT, Kreatinin
References
[1] Kementerian Kesehatan Republik Indonesia. (2020). Pedoman nasional tatalaksana klinis infeksi HIV dan terapi antiretroviral pada orang dewasa. Kementerian Kesehatan RI.
[2] World Health Organization. (2023). Global HIV statistics, 2023. WHO.
[3] Kementerian Kesehatan Republik Indonesia. (2024). Laporan Situasi Perkembangan HIV/AIDS di Indonesia. Kementerian Kesehatan RI.
[4] Safira, N., Fahdhy, M., (2023). Pengetahuan dan Sikap tentang Penyakit Infeksi Menular Seksual (PIMS) di Kalangan Mahasiswa. Jurnal Semesta Sehat 3(2). 54-64. https://jsemesta.iakmi.or.id/index.php/jm/article/view/110
[5] Dinas Kesehatan Provinsi Papua. (2025). Data Populasi HIV/AIDS tahun 2025. Dinas Kesehatan Provinsi Papua.
[6] Ray, A. S. (2016). Renal effects of tenofovir disoproxil fumarate: Clinical relevance. Current Opinion in HIV and AIDS, 11(6), 606–612.
[7] Sunaidi, A. (2023). Pemeriksaan enzim hati SGOT pada pasien dengan gangguan fungsi hati. Jurnal Kesehatan Klinik.
[8] Novelia, S. (2016). Pemeriksaan Serum Glutamic Pyruvic Transaminase (SGPT) pada kerusakan hati. Jurnal Analis Kesehatan.
[9] Corwin, E. J. (2001). Handbook of pathophysiology (2nd ed.). Lippincott Williams & Wilkins.
[10] Nasronudin. (2007). HIV & AIDS: Pendekatan biologi molekuler, klinis, dan sosial. Airlangga University Press.
[11] Sinaga, H., Hasim, MH., (2019). Pemeriksaan fungsi hati pada penderita HIV dengan terapi ARV ? 6 bulan di RS Marthen Indey Jayapura. Jurnal Kesehatan. 8(1) : 28-34.
[12] Lyfanni, R. (2021). Pengaruh penggunaan obat antipsikotik terhadap kadar enzim hati: Tinjauan pada pasien HIV/AIDS. Jurnal Farmasi Klinis.
[13] Yudhasawra, A, N., Susilawati, N. M. ., & Djawa Udju, S. (2024). Hubungan Lama Pengobatan Dengan Kadar SGOT dan SGPT Pada Pasien Tuberkulosis. Journal of Nursing and Health, 9(3), 299-306. https://doi.org/10.52488/jnh.v9i3.373
[14] Lopes, E. P., Ferraz, M. L., de Jesus, R. P. (2013). Subclinical hepatic abnormalities in HIV-infected patients. BMC Infectious Diseases, 13, 157.
[15] Limdi, J. K., & Hyde, G. M. (2003). Evaluation of abnormal liver function tests. Postgraduate Medical Journal, 79(932), 307-312.
[16] Cooper, R. D., Wiebe, N., Smith, N., Keiser, P., Naicker, S., & Tonelli, M. (2010). Systematic review and meta-analysis: Renal safety of tenofovir disoproxil fumarate in HIV-infected patients. Clinical Infectious Diseases, 51(5), 496–505.
[17] Kalyesubula, R., & Perazella, M. A. (2011). Nephrotoxicity of HAART. AIDS Research and Treatment, 2011.
[18] Milburn, J., Jones, R., Levy, J. B., & Connolly, J. O. (2016). Renal effects of novel antiretroviral drugs. Nephrology Dialysis Transplantation, 31(6), 861–867.
[19] Yombi, J. C., Pozniak, A., Boffito, M., (2014). Antiretrovirals and the kidney in current clinical practice: Renal pharmacokinetics, alterations of renal function, and renal toxicity. AIDS, 28(5), 621–632.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Jurnal Sains dan Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
