Analisis Efektivitas Biaya Amitriptilin dan Gabapentin pada Pasien Stroke dengan Nyeri Neuropati di Instalasi Rawat Inap RSUD Provinsi NTB Tahun 2017
DOI:
https://doi.org/10.25026/jsk.v2i4.186Abstract
Neuropathic pain which is suffered by stroke patients is a pain that occurred because of the damage of the somato sensory system. The first-line therapy of neuropathic pain can be done by using amitriptyline and gabapentin. Both amitriptyline and gabapentin have significant cost-effectiveness differences. This research aims to investigate the cost effectiveness of both amitriptyline and gabapentin through stroke patients who suffered neuropathic pain. The techniques of data collection applied to a total sampling which are 17 samples were collected. The data were retrospective by the year of 2017, meanwhile, the research was conducted from April to July 2019. Clinical evaluation of neuropathic pain is conducted by applying the Wong Baker Pain Rating Scale. Amitriptyline and gabapentin cost effectiveness analysis showed Average Cost-Effectiveness Ratio (ACER) are Rp 45.443,08 and Rp 52.241,52 and Incremental Cost-Effectiveness Ratio (ICER) Rp 72.636,87. Based on the results, Incremental Net Benefit (INB) showed that gabapentin is the most cost-effective than amitrityline with Rp + 59.078,37 score.
Keywords: Stroke, neuropathic pain, amitriptyline, gabapentin, cost-effectiveness analysis
References
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[27] Marhenta, Y.B., Siwi, M.A.A. dan Aprilianur, D. 2018. Analisis Efektivitas Biaya Terapi Kombinasi Antihipertensi Pasien Hipertensi dengan Penyerta Diabetes Mellitus Tipe-2 di RSU Aminah Blitar. Jurnal Wiyata, 5(1), 44-51
[28] Cazarim, M.D.S. dan Pereira, L.R.L. 2018. Cost-Effectiveness Analysis of Pharmaceutical Care of Hypertensive Patients from the Perspective of the Public Health System in Brazil. Plos One, 13( 3), 1-16
[29] Hartwell, D., Cooper, K., Frampton, G.K., Baxter, L. dan Loveman, E. 2014. The Clinical Effectiveness and Cost-Effectiveness of Peginterferon Alfa and Ribavirin for the Treatment of Chronic Hepatitis C in Children and Young People: A Systematic Review and Economic Evaluation. Health Technology Assessment, 18( 65), 201
[2] Cruccu, G. dan Truini, A, 2017. A Review of Neuropathic Pain: From Guidelines to Clinical Practice. Pain and Therapy, 6(1), 35-42
[3] Utami, P., Ikawati, Z. dan Setyaningsih, 2013. Perbandingan Efek Terapi Gabapentin dan Amitriptilin pada Pasien Stroke dengan Nyeri Neuropati. Mutiara Medika, 13( 2), 89-97
[4] Kementerian Kesehatan RI. 2018. Kebijakan dan Strategi Pencegahan dan Pengendalian Stroke di Indonesia. Jakarta: Kementerian Kesehatan RI.
[5] Kementerian Kesehatan RI.2012. Keputusan Menteri Kesehatan Republik Indonesia Nomor 092/MENKES/SK/II/2012 tentang Harga Eceran Tertinggi Obat Generik Tahun 2012. Jakarta: Kementerian Kesehatan RI.
[6] Kementerian Kesehatan RI. 2013. Pedoman Penerapan Kajian Farmakoekonomi. Jakarta: Kementerian Kesehatan RI.
[7] RSUD Provinsi NTB. 2018. Rumah Sakit Umum Daerah Provinsi NTB. Diakses dari https://www.rsud.ntbprov.go.id
[8] Cazarim, M.D.S. dan Pereira, L.R.L, 2018. Cost-Effectiveness Analysis of Pharmaceutical Care of Hypertensive Patients from the Perspective of the Public Health System in Brazil. Plos One, 13( 3), 1-16
[9] Andayani, T.M. 2013. Farmakoekonomi Prinsip dan Metodologi. Yogyakarta: Bursa Ilm
[10] Pajri, R.N., Safri dan Dewi, Y.I. 2018. Gambaran Faktor-faktor Penyebab Terjadinya Stroke. Jurnal Online Mahasiswa (JOM) Universitas Riau, 5, 436-444.
[11] Hanum, P., Lubis, R. dan Rasmaliah. 2018. Hubungan Karakteristik dan Dukungan Keluarga Lansia dengan Kejadian Stroke pada Lansia Hipertensi di Rumah Sakit Umum Pusat Haji Adam Malik Medan. Jumantik, 3(1), 72-88
[12] Appelros, P., Stegmayr, B. dan Terent, A. 2009. Sex Differences in Stroke Epidemiology: A Systematic Review. Stroke, 40(4) , 1082-1090
[13] Yueniwati, Y. 2015. Deteksi Dini Stroke Iskemia dengan Pemeriksaan Ultrasonografi Vaskular dan Variasi Genetika. Malang: Universitas Brawijaya Press
[14] Sofwan, R. (2013). Stroke dan Rehabilitasi Pasca-Stroke. Jakarta: Bhuana Ilmu Populer
[15] Binder, A. dan Baron, R. 2016. The Pharmacological Therapy of Chronic Neuropathic Pain. Deutsches Arzteblatt International, 113, 616-626
[16] Garra, G., Singer, A.J., Taira, B.R., Chohan, J., Cardoz, H., Chisena, E. Dan Thode, H.C. 2009. Validation of the Wong-Baker Faces Pain Rating Scale in Pediatric Emergency Department Patients. Society for Academic Emergency Medicine, 17( 1), 50-54
[17] Feladita, N., Satibi dan Marchaban. 2014. Analisis Biaya Terapi Stroke Hemoragi pada Pasien Rawat Inap. Jurnal Manajemen dan Pelayanan Farmasi, 4 (2) 69-76
[18] Aulia, D., Ayu, S.F. dan Nefonafratilova. 2017. Analisis Perbandingan Biaya Langsung (Direct Cost) dan Biaya Tidak Langsung (Indirect Cost) pada Pasien Stroke di Rumah Sakit. Jurnal Ekonomi Kesehatan Indonesia, 2 (2) , 82-88
[19] Setyawan, I.A., Andayani, T.M. dan Pinzon, R.T. 2016. Analisis Biaya Penyakit Stroke Perdarahan di Rumah Sakit. Jurnal Manajemen dan Pelayanan Farmasi, 6( 1), 41-46
[20] Greater Manchester Medicines Management Group. 2014. Neuropathic Pain Guideline. Manchester: Greater Manchester Medicines Management Group
[21] Cavalli, E., Mammana, S., Nicoletti, F., Bramanti, P. dan Mazzon, E.2019. The Neuropathic Pain: an Overview of the Current Treatment and Future Therapeutic Approaches. International Journal of Immunopathology and Pharmacology, 33, 1-10.
[22] Baroroh, F. dan Fathonah, S.S. (2017). Biaya Medik Langsung Terapi Hipertensi Pasien Rawat Jalan di Rumah Sakit X Yogyakarta. Jurnal Farmasi Sains dan Praktis, 3( 2), 6-13
[23] Attal, N. dan Bouhassira, D. 2015. Pharmacotherapy Of Neuropathic Pain: Which Drugs, Which Treatment Algorithms?. Pain, 156(4), 104-114
[24] Wiffen, P.J., Derry, S., Bell, R.F., Rice, A.S.C., Tolle, T.R., Phillips, T. dan Moore, R.A. 2019. Gabapentin for Chronic Neuropathic Pain in Adults (Review). John Willey and Sons
[25] Sekar, P., Punnagai, K. dan David, D.C. 2017. Comparative Study of Safety and Efficacy of Gabapentin Versus Amitriptyline in Patients with Painful Diabetic Peripheral Neuropathy, a Randomized Open Label Parallel Group Study. Biomedical and Pharmacology Journal, 10 (3), 1259-1265
[26] Hesami, O., Gharagozli, K., Beladimoghadam, N., Assarzadegan, F., Mansouri, B. dan Sistanizad, M. 2015. The Efficacy of Gabapentin in Patients with Central Post-Stroke Pain. Journal of Pharmaceutical Research, 14, 95-101
[27] Marhenta, Y.B., Siwi, M.A.A. dan Aprilianur, D. 2018. Analisis Efektivitas Biaya Terapi Kombinasi Antihipertensi Pasien Hipertensi dengan Penyerta Diabetes Mellitus Tipe-2 di RSU Aminah Blitar. Jurnal Wiyata, 5(1), 44-51
[28] Cazarim, M.D.S. dan Pereira, L.R.L. 2018. Cost-Effectiveness Analysis of Pharmaceutical Care of Hypertensive Patients from the Perspective of the Public Health System in Brazil. Plos One, 13( 3), 1-16
[29] Hartwell, D., Cooper, K., Frampton, G.K., Baxter, L. dan Loveman, E. 2014. The Clinical Effectiveness and Cost-Effectiveness of Peginterferon Alfa and Ribavirin for the Treatment of Chronic Hepatitis C in Children and Young People: A Systematic Review and Economic Evaluation. Health Technology Assessment, 18( 65), 201
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Published
2020-12-31
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Pratiwi F, Puspitasari CE, Erwinayanti GS, Widiyastuti R. Analisis Efektivitas Biaya Amitriptilin dan Gabapentin pada Pasien Stroke dengan Nyeri Neuropati di Instalasi Rawat Inap RSUD Provinsi NTB Tahun 2017. J. Sains Kes. [Internet]. 2020 Dec. 31 [cited 2026 Jun. 21];2(4):373-8. Available from: https://jsk.jurnalfamul.com/index.php/jsk/article/view/186
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