Analisis Efektivitas Biaya Pengobatan Medis pada Pasien Glaukoma Primer Sudut Terbuka dengan Kombinasi Obat Latanoprost-Betaxolol dengan Latanoprost-Timolol di Rumah Sakit Mata Cicendo
Analysis of the Cost Effectiveness of Medical Treatment in Patients with Primary Open-Angle Glaucoma Treated with a Combination of Latanoprost-Betaxolol and Latanoprost-Timolol at Cicendo Eye Hospital
DOI:
https://doi.org/10.25026/jsk.v7i6.2553Abstract
Glaucoma is the second leading cause of blindness after cataracts and is permanent. Glaucoma therapy involves the use of prostaglandin analogues, adrenergic blocking agents, or a combination of both. Various therapeutic issues related to cost have been identified when considering combination drugs and their effectiveness. This study aims to determine the use of glaucoma drugs combination medications that are most cost-effective for patients at Cicendo Eye Hospital using latanoprost, latanoprost+betaxolol, and latanoprost+timolol. The study design is a retrospective descriptive observational study with a pharmacoeconomic analysis approach using outpatient medical records. The most commonly used combination medications belongs to the prostaglandin analog and adrenergic blocking agent class, namely latanoprost+timolol (74.51%), latanoprost+betaxolol (17.65%), and latanoprost (7.84%). The combination of latanoprost+timolol 0.5% is considered the most cost-effective therapy for Open-Angle Glaucoma with an ACER value of Rp 11,853 and an ICER of Rp 41,003.58.
Keywords: Cost-Effectiveness Analysis, Glaucoma, Combination Drugs
Abstrak
Glaukoma merupakan penyebab kebutaan kedua terbanyak setelah katarak dan bersifat permanen. Terapi glaukoma adalah dengan pengobatan golongan analog prostaglandin, adrenergic blocking agent, termasuk kombinasi keduanya. Ditemukan berbagai permasalahan terapi terkait sisi biaya dengan melihat obat kombinasi dan keefektifannya. Penelitian ini bertujuan untuk mengetahui penggunaan obat glaucoma kombinasi yang paling cost-effective pada pasien di RS Mata Cicendo dengan terapi latanoprost, latanoprost+betaxolol, latanoprost+timolol. Desain penelitian ini adalah observasi retrosfektif deskriptif dengan pendekatan analisis farmakoekonomi dari data rekam medik pasien rawat jalan. Obat kombinas yang paling banyak digunakan adalah golongan Analog prostaglandin & adrenergic blocking agent yaitu latanoprost+timolol (74,51%), latanoprost+betaxolol (17,65%) dan latanoprost (7,84%). Kombinasi latanoprost+timolol 0,5% dinilai sebagai terapi paling cost-effective untuk Glaukoma Sudut Terbuka dengan nilai ACER sebesar Rp 11.853 dan ICER Rp 41.003,58.
Kata Kunci: Analisis Efektifitas Biaya, Glaukoma, Obat kombinasi
References
[1] Akhyani, N., Pambudi, R. S., Khusna, K., Farmasi, P. S., Sains, F., & Surakarta, U. S. (2024). Efektivitas Biaya Antibiotik Pada Pasien Demam Tifoid di Klinik X Sragen. 20(4), 549–557.
[2] Fathurrahman, M. H., Simanjuntak, N., & Sopiah, N. S. (2023). Analisis Efektivitas Biaya Penggunaan Obat Pada Pasien Rawat Inap Penyakit Covid-19 Kategori Suspek Non-Comorbid Dengan Terapi Obat Kombinasi Antivirus Dan Antibiotik Di Salah Satu Rumah Sakit Kota Bandung Periode Juli – Desember 2021. Pharma Xplore?: Jurnal Sains Dan Ilmu Farmasi, 8(1), 24–34. https://doi.org/10.36805/jpx.v8i1.5251
[3] Barbosa, L. E. O., Barboza, W. L., Guedes, R. A. P., Chaoubah, A., & Hatanaka, M. (2025). Cost-effectiveness of selective laser trabeculoplasty as a replacement for hypotensive eye drops in the Brazilian public health system. Clinics, 80. https://doi.org/10.1016/j.clinsp.2025.100650
[4] Song, D., & Wang, L. (2024). Cost-utility analysis of treating mild stage normal tension glaucoma by surgery in China: a decision-analytic Markov model. Cost Effectiveness and Resource Allocation, 22(1), 1–9. https://doi.org/10.1186/s12962-024-00523-6
[5] Lei, Q., Tu, H., Feng, X., Ortega-Usobiaga, J., Cao, D., & Wang, Y. (2021). Distribution of ocular biometric parameters and optimal model of anterior chamber depth regression in 28,709 adult cataract patients in China using swept?source optical biometry. BMC Ophthalmology, 21(1), 1–8. https://doi.org/10.1186/s12886-021-01932-4
[6] Schwenn, O., Heckmann, B., Guzy, C., & Miller, P. J. (2010). Long-term effect of latanoprost/timolol fixed combination in patients with glaucoma or ocular hypertension: A prospective, observational, noninterventional study. BMC Ophthalmology, 10(1), 1–9. https://doi.org/10.1186/1471-2415-10-21
[7] Radcliffe, N., Berdahl, J., Ibach, M., Schweitzer, J., Levine, J., & McCafferty, S. (2020). Improved efficacy of topical latanoprost 0.005% demonstrated by corneal biomechanical correcting modified goldmann prism. Clinical Ophthalmology, 14, 2245–2253. https://doi.org/10.2147/OPTH.S264055
[8] Hommer, A., Sperl, P., Resch, H., Popa-Cherecheanu, A., Qiao, C., Schmetterer, L., & Garhöfer, G. (2012). A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension. Journal of Ocular Pharmacology and Therapeutics, 28(6), 569–575. https://doi.org/10.1089/jop.2011.0165
[9] Virani, S., & Rewri, P. (2024). A Narrative Review of Pharmacotherapy of Glaucoma. Future Pharmacology, 4(2), 395–419. https://doi.org/10.3390/futurepharmacol4020022
[10] Winkler, N. S., & Fautsch, M. P. (2014). Effects of prostaglandin analogues on aqueous humor outflow pathways. Journal of Ocular Pharmacology and Therapeutics, 30(2–3), 102–109. https://doi.org/10.1089/jop.2013.0179
[11] Cheng, J. W., Cheng, S. W., Gao, L. Di, Lu, G. C., & Wei, R. L. (2012). Intraocular Pressure-Lowering Effects of Commonly Used Fixed-Combination Drugs with Timolol: A Systematic Review and Meta-Analysis. PLoS ONE, 7(9). https://doi.org/10.1371/journal.pone.0045079
[12] Toumanidou, V., Diafas, A., Georgiadis, N., & Tsinopoulos, I. (2023). Fixed versus Unfixed Combination of Topical Latanoprost/Timolol for Glaucoma: An Observational Study Investigating the Level of Adherence and Ocular Surface Health. Journal of Clinical Medicine, 12(9). https://doi.org/10.3390/jcm12093137
[13] Lee, Y., Park, D. J., & Ko, S. K. (2014). Cost-Effectiveness Analysis of Latanoprost Compared with Dorzolamide/Timolol Fixed Combination for the Treatment of Open-Angle Glaucoma and Ocular Hypertension Patients in Korea. Value in Health, 17(7), A782. https://doi.org/10.1016/j.jval.2014.08.382
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Jurnal Sains dan Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
