Potensi Senyawa Metabolit Sekunder Dari Kulit Batang Melochia umbellata (Houtt) Stapf var. degrabrata paliasa) Sebagai Anti-Tuberkulosis
DOI:
https://doi.org/10.25026/jsk.v1i4.38Keywords:
P otensi anti - tuberkulosis, ekstrak metanol dan tumbuhan M. umbellata (paliasa)Abstract
Melochia umbellata (Houtt) Stapf var. Degrabrata merupakan jenis tumbuhan yang banyak ditemukan di hutan tropis Indonesia. Di daerah Sulawesi selatan tumbuhan ini dikenal dengan nama paliasa dan sejak lama digunakan oleh masyarakat setempat sebagai bahan obat tradisional. Tujuan penelitian ini adalah menentukan senyawa golongan metabolit sekunder menentukan potensi anti-TB ekstrak metanol dari kulit batang M. umbellata. Hasil penelitian ini menunjukkan bahwa ekstrak metanol dari kulit batang M. umbellata (Houtt) Stapf var. degrabrata mengandung senyawa golongan metabolit sekunder seperti: alkaloid, flavonoid, triterpenoid, steroid dan fenolik. Hasil uji biaoaktivitas menunjukkan bahwa ekstrak metanol kulit batang M. umbellata berpotensi sebagai anti-TB dengan memperlihatkan daya hambat terhadap pertumbuhan Mycobacterium tuberculosis galur H37Rv. pada konsentrasi 100 ppm dan 200 ppm.
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22. Bonjar GHS, Nik AK, Aghighi S. 2004. Antibacterial and antifungal survey in plants used in indigenous herbal-medicine of south eastregions of Iran. J Biol Sci.; 4: 405-412.
23. Shimada T. Salivary proteins as a defense against dietary tannins. J. Chem. Ecol. 2006; 32: 1149-1163.
24. Raquel F. Epand, 2007. Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds. Biochimica et Biophysica Acta.; 2500–2509.
2. Gan, Li-She, Ren, G., Mo, Jian-Xia, Zhang, Xiang-Yi, Yao, W., and Zhou Chang-Xin, 2009, Cycloartane Triterpenoids from Kleinhovia
hospital Linn, J. Nat. Prod., 72, 1102–1105.
3. Igoli, J. O., Ogaji, O. G., Tor-Anyiin, T. A., Igoli, N.P. (2005). Medicinal Practices among the Igede people of Nigeria Part II, African Journal of Complementary and Alternative Medicine, Vol.2, Ibrahim T.Babalola, Esther A. Adelakun, Yuehong Wang, Francis O. Shode Vol. 1 No. 3 2012 www.phytojournal.com Page | 26
4. Babalola, I.T., Adelakun E.A., Wang Y, Shode, F.O., 2012, Anti-TB
Activity of Sterculia setigera Del., Leaves (Sterculiaceae), Journal of Pharmacognosy and Phytochemistry. Vol. 1 No. 3, Online Available at www.phytojournal.com.
5. Tayeb, R., Alam, G., Wahyudin, E., 2007. Toksisitas Ekstrak Daun Paliasa Jenis Kleinhovia hospita, Melochia umbellata var. Degrabrata
dan M. umbellatavar. Visenia Terhadap Larva A. salina Leach. Majalah Obat Tradsional..
6. Raflizar., Adimunca., dan Tuminah, S.2006. Dekok Daun Paliasa (Kleinhovia hospitalLinn) Sebagai Obat Radang Hati Akut. Cermin Dunia Kedokteran. 50, 10-14.
7. Lalo, A., 2003. Perbandingan Efek Ekstrak Metanol Berbagai Jenis Daun Paliasa Terhadap Fyngsi Hati Mencit Jantan, Skripsi, Jurusan Farmasi FMIPA Unhas Makassar.
8. Erwin, Noor, A., Soekamto, N.H., Harlim T. 2009, Skrining Bioaktivitas Beberapa Bagian Jaringan Tumbuhan Paliasa, Melochia
umbellata(Houtt). Stapf var. Degrabrata. J. Indonesian Chemica Acta, Vol. 2, No. 1, Juni 2009.
9. Ridhay, A., Noor, A., Soekamto, N.H., dan Harlim, T., 2011. Isolasi dan Uji Antibakteri Senyawa Steroid dari Kayu Akar M. umbellate(Houtt) Stapf var. degrabrata K. JurnalKesehatan Bung, 1(4): 43 –46, Desesmber 2011
10. Erwin, Noor, A., Soekamto, N.H., Harlim T. 2010, PenentuanStruktur Molekul Isolat Kayu Batang Melochia umbellate (Houtt). Stapf var. Degrabrata K (Paliasa) dan Uji Sel Murin Leukimia
P-388. Disertasi, tidak diterbitkan, Program Studi Kimia PPS UNHAS, Makassar.
11. Mann A, Amupitan J.O, Oyewale A.O, Okogun J.I , Ibrahim K, Oladosu P, Lawson I, Olajide I and Nnamdi A (2008).Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment ofrespiratory diseases .African Journal of Biotechnology 7 (11):1630-
1636.
12. Almagboul, A.Z., Bashiru, A.K., Farouk, A., Salih, A.K. (1988). Antimicrobial Activity of Certain Sudanese Plants Used in Folklorik Medicine: Screening for Antibacterial Activity (1V). J. Fitoterapia,Vol. 56 (6) pp.331-337
13. Adeniyi, B.A., Groves, M.J., and Gangadharam, P.R., (2004). In Vitro Antimycobacterial Activities of Three Spesies of Cola Plantextracts (Sterculiaceae),Phytother Res, 18: 414 –418.
14. Sonibare M. A, Soladoye M.O, Esan O.O, and Sonibare O.O, 2009, “Phytochemical and antimicrobial studies of four species of Cola
Schott & Endl. (Sterculiaceae),” African Journalof Traditional, Complementary and Alternative Medicines, vol. 6, no. 4, pp. 518–525.
15. Sowmya G.S., Vinayachandra, Syed Hidayathulla and K.R. Chandrashekar. 2011. Antimicrobial Activity and Phytochemical Screening of Pterospermum reticulatum Wight and ARN, International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 3,5,2011
16. Heyne, K., 1987, Tumbuhan Berguna Indonesia,Jilid II, Yayasan sarana Warna Jaya, Jakarta.
17. Watson, L., Dalwit, M.J. 1992. The Famillies of Flowering Plants Sterculiaceae Vent. (online) (http://www.Sterculiaceae.html) diakses 20 Maret 2010.
18. Soekamto, N.H., Noor, A., Dini, I., Rudiansyah and Merry, G. 2008.
Coumarin and Steroid Compound from Stem Bark of Kleinhovia hospital Linn. Proceeding on the International Seminar on Chemistry 2008, The Role of Chemistry in The Utilization of Natural Resources,
Bandung 30 –31 October.
19. Noor, A., Kumanireng, A.S., 2004. Isolasi dan Identifikasi Konstituen Organik Tanaman Daun Paliasa (Kleinhovia hospita Linn) pada Kelarutan Berdasarkan Kelompok Polaritasnya. TPSDP BATCH II UnhasMakassar.
20. Hanaa FM Ali, Hossam S, El-beltagi and Nasr F Nasr. 2011.Evaluation of antioxidant and antimicrobial activity of Aloysia triphylla. Electronic Journal of Environmental, Agricultural and food Chemistry 10(8):2689-2699.
21. Calderon C.B, Sabundayo B.P., 2007. Antimicrobial Classifications: Drugs fo, J.r Bugs. In Schwalbe R, Steele-Moore L, Goodwin AC. Antimicrobial Susceptibility Testing Protocols.CRC Press. Taylor & Frances group. ISBN 978-0-8247-4100-6.
22. Bonjar GHS, Nik AK, Aghighi S. 2004. Antibacterial and antifungal survey in plants used in indigenous herbal-medicine of south eastregions of Iran. J Biol Sci.; 4: 405-412.
23. Shimada T. Salivary proteins as a defense against dietary tannins. J. Chem. Ecol. 2006; 32: 1149-1163.
24. Raquel F. Epand, 2007. Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds. Biochimica et Biophysica Acta.; 2500–2509.
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Published
2015-12-31
How to Cite
Usman, U. (2015). Potensi Senyawa Metabolit Sekunder Dari Kulit Batang Melochia umbellata (Houtt) Stapf var. degrabrata paliasa) Sebagai Anti-Tuberkulosis. Jurnal Sains Dan Kesehatan, 1(4), 188–194. https://doi.org/10.25026/jsk.v1i4.38
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